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glutathione cellular antioxidant benefits system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis Size:60g
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In GBM, elevated IDO1 expression correlates with tumor progression and poor prognosis, partly by suppressing ferroptosis via stabilizing SLC7A11 mRNA through FTO-dependent m6A methylation [89]
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The link between ammonia-induced cell death and necrosis is likely due to the local accumulation of ammonia at high concentrations, which disrupts cell membrane integrity and initiates necrotic responses such as cell swelling, membrane rupture, and the leakage of intracellular components into the extracellular space (117, 118)
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