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Recent studies have emphasized mitochondria as crucial regulators of innate immunity, with mitochondrial DNA (mtDNA) being released into the cytoplasm, extracellular space, or bloodstream to activate multiple innate immune signaling pathways [62]
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At-risk groups include vegans and vegetarians (since most dietary sources of vitamin B12 are animal products), or people whose bodies may not absorb enough of the vitamin due to: Age (60+) Gastrointestinal diseases (like Crohn’s, ulcerative colitis, or celiac disease) Pernicious anemia Bariatric surgery Long term use of proton-pump inhibitors or H2 blockers “If people in these groups have noticed a change in their mood recently, they may want to investigate B12,” says Begdache
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