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Inhibitors such as orlistat and TVB-2640 directly induce cancer cell apoptosis and reverse drug resistance by inhibiting FASN activity.TVB-2640 has been clinically tested to reduce liver fat content and improve metabolic indicators in patients [109],and new inhibitors such as 6p have reduced the tumor volume of non-small cell lung cancer and melanoma by over 50% in animal models, and significantly improved efficacy when combined with cisplatinum (inhibition rate of 87%) [110].These advances highlight the broad prospects of FASN inhibitors as metabolic targeting therapy, especially for patients with breast cancer with high FASN expression

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In individuals with MASLD, the coexistence of metabolic dysfunction and ethanol intake exacerbates nutritional deficits, leading to the depletion of essential micronutrients with significant consequences for hepatic, immune, and muscular function [85]