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Metformin: First-line oral antihyperglycemic drug commonly used in type 2 diabetes. Its most common adverse effects are gastrointestinal, while vitamin B12 deficiency can develop with long-term use and lactic acidosis is rare

Despite its great effectiveness, this approach is expensive, making it unsuitable for widespread use [17]

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One of the most common tendon conditions affecting the knee is patellar tendinopathy, often referred to as “ jumper’s knee .” Rather than representing a single traumatic injury, this condition usually develops gradually through repetitive loading that exceeds the tendon’s ability to recover