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Your healthcare provider will likely arrange blood tests to evaluate: HbA1c and glucose profiles – to assess glycaemic control and recent changes Vitamin B12 levels – particularly important if you take metformin Folate levels – to exclude deficiency that may contribute to neuropathy Thyroid function – as hypothyroidism can cause peripheral neuropathy Renal function – to exclude uraemic neuropathy Full blood count – to identify anaemia or other haematological issues Depending on findings, further investigations such as nerve conduction studies or referral to neurology may be warranted for persistent, severe or atypical symptoms

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The researchers indicated that MOTS-c may potentially impact cellular metabolism by inhibiting the folate cycle, directly tethering de novo purine biosynthesis, consequently leading to AMPK activation